Easily accessible engineering software to calculate the airborne and impact sound insulation of structural components are a shortage, which hinders the development of new efficient building systems and the inclusion of new environmentally friendly building materials. There are some good possibilities today to calculate field values using commercial programs following the series ISO 12354. However, these standards need to be fed with lab measurements or calculations of each product combination, and all possible product combinations can never be measured. Therefore, calculation tools for various floor and wall configurations are the key for the future development of new building systems and the verification of new materials in the structural components. Few software are available to calculate sound insulation for walls and floors in buildings. Stora Enso offers the CLT software “Calculatis”, Marshall Day Acoustics provides “INSUL 10” and the company Sonusoft provides the software “Acoulatis”. The three software have slightly different approaches, and so is their capability to calculate various wall and floor structures for CLT. In this paper, a detailed comparative analysis between the software is carried out, based on CLT combinations. The results presented also include comparisons to measured lab values in third octaves, single numbers, and spectrum adaptation terms.